General Surgery Faculty

Faculty: General Surgery

Brad G Hoffman, PhD

Assistant Professor
Active Staff - Scientist Level 1, CFRI

Address:
Child & Family Research Institute
A4-185, 950 West 28^th Avenue
Vancouver, BC V5Z 4H4

Phone: 604.875.2000 ext 7014

Fax: 604.875.2373

Focus

Understanding how the genes critical to endocrine pancreas development, as well as β-cell function and proliferation are regulated is essential for the development of novel strategies for the production of insulin-secreting cells, and for improving the efficacy of available transplantable material. The recent development of several novel experimental techniques is beginning to make the elucidation of the mechanisms behind the control of β-cell critical genes, on a global basis, a feasible and tractable task in mammalian biology. The utilization of these techniques to understand endocrine pancreas development and function is highly novel and potentially extremely significant in advancing our understanding of these processes and is the focus of our research.

scholarly, professional activities

Selected Publications

Hoffman BG, Beach M, Callum R, Roberston G, Zavaglia B, Wederell E, Soukhatcheva G, Dai D, Thiessen N, Bilenky M, Verchere B, Helgason CD, Marra M, Jones S, Hoodless PA. Specification of islet and liver gene expression by tissue specific Foxa2 binding and recruitment of Pdx1 and Hnf4β. Manuscript in preparation

Hoffman BG, Jones S. Application of ChIP-Seq to the investigation of transcriptional networks in endocrine organs. Invited review submitted to the Journal of Endocrinology.

Morozova O, Morozova V, Hoffman BG, Helagason CD, Marra MA, A seriation approach for visualization-driven discovery of co-expression patterns in serial analysis of gene expression (SAGE) data. PLoS ONE; Sep 12;3(9):e3205, 2008

Hoffman BG, Zavaglia B, Witzsche J, Beach M, & Helgason CD. Expression of the Groucho/Tle proteins during pancreas development. BMC Developmental Biology; Sep 8, 8:81, 2008. Highly Accessed

Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Thiessen N, Bilenky M, Hoodless PA, Jones S, Marra M, & Helgason CD. Identification of Transcripts with Enriched Expression in the Developing and Adult Pancreas. Genome Biology; 9(6): R99, June 14, 2008. Highly Accessed

Hoffman BG, Williams K, Tien AH, Lu V, Ruiz de Algara T, Ting JPY & Helgason CD. Identification of Novel Genes and Transcription Factors Involved in Spleen, Thymus, and Immunological Development and Function. Genes and Immunity (PMID: 16355110); 7(2): 101-112, 2006.

Zhang T*, Hoffman BG*, Ruiz de Algara T, & Helgason CD. SAGE reveals expression of Wnt signalling pathway members during mouse prostate development. Gene Expression Patterns (PMID: 16378759); 6(3): 310-324, 2006. *These authors contributed equally to this work

Siddiqui AS, Khattra J, Delaney AD, Zhao Y, Astell C, Asano J, Babakaiff, Barber S, Beland J, Bohacec S, Brown-John M, Chand S, Charters AM, Cullum R, Dhalla N, Featherstone R, Gerhard DS, Hoffman BG, Holt R, Hou J, Kuo B Y-L, Lee Lisa LC, Lee S, Leung D, Ma K, Matsuo C, Mayo M, McDonald H, Prabhu A-L, Pandoh P, Riggins GJ, Ruiz de Algara T, Rupert JL, Smailus D, Stott J, Tsai M, Varhol R, Vrljicak P, Wong D, Wu MK, Xie Yuan-Yun, Yang G, Zhang I, Hirst M, Jones SJM, Helgason CD, Simpson EM, Hoodless PA, Marra Marco. A mouse atlas of Gene Expression: A public, large-scale, digital gene expression profiling resource from precisely defined developing C57BL/6J mouse tissues and cells. PNAS. 102(51): 18485-18490, 2005. This paper was listed as one of the "top 20" most viewed papers in PNAS.