Faculty: General Surgery

Sam Wiseman

Associate Professor
Michael Smith Scholar
Active Staff, St. Paul's Hospital

City: Vancouver
Hospital Authority: Vancouver Coastal Health

Clinical office Address:
Room C303, Burrard Building
Department of Surgery
St. Paul's Hospital
1081 Burrard Street
Vancouver, BC, V6Z 1Y6

  Phone:   604.806.9108

  Fax:   604.806.9957

  Email:   smwiseman@providencehealth.bc.ca

Special Interests

• General Surgery
• Endocrine Surgery
• Surgical Oncology
• Clinical/Translational Research
• Teaching

TEACHING (Areas of special interest and accomplishments)

• Management of thyroid and parathyroid tumors
• Management of salivary gland tumors
• Molecular basis of endocrine, colorectal, and breast cancer

SCHOLARLY AND PROFESSIONAL ACTIVITIES
(Areas of special interest and accomplishments)

• Study of genomic instability of thyroid, breast, and colorectal cancers
• Study of targeted therapeutics for treatment of thyroid, breast, and colorectal cancers
• Study of type 1 growth factor receptor family in colorectal, thyroid, and breast cancers
• Study of Autocrine Motility Factor expression in colorectal, thyroid, and breast cancers
• Study of 'anaplastic transformation' of differentiated thyroid cancer
• Study of molecular targets for therapy of anaplastic thyroid cancer
• Novel application of sentinel node biopsy methodologies to human malignancy
• Study of surgical outcomes of HIV/AIDS patients
• Study of management of tertiary hyperparathyroidism

Selected Publications

Wiseman SM, Tan D, Hill HC :
The Double Pylorus A Report Of 2 Cases And Clinicopathologic Review. Endoscopy (2005) 37:277.

Said M, Wiseman SM, Yang J, Al Rawi S, Douglas W, Cheney R, Hicks W, Rigual N, Loree T, Spiegel G, Tan D :
Tissue Esinophilia: A Morphologic Marker for Assessing Stromal Invasion in Laryngeal Squamous Neoplasms. BMC Clinical Pathology (2005)5:1-8.

Wiseman SM, Makretsov N, Nielsen T, Gilks CB, Yorida E, Cheang MCU, Turbin D, Gelmon K, Huntsman D :
Co-expression of the Type 1 Growth Factor Receptor Family Members HER1, HER2 and HER3 Has a Synergistic Negative Prognostic Effect on Breast Cancer Survival. Cancer (2005) 103(9):1770-1777.

Baliski C, Stewart J, Anderson D,Wiseman SM, Bugis S :
Selective Unilateral Parathyroid Exploration- An Effective Treatment of Primary Hyperparathyroidism. American Journal of Surgery (2005) 189:596-600.

Piper H, Bugis S, Wilkins G, Walker B, Wiseman SM, Baliski C :
Detecting and Defining Hypothyroidism After Hemithyroidectomy. American Journal of Surgery (2005) 189:587-591.

Douglas WG, Rigual NR, Geise W, Bauer J, Wiseman SM, Loree TR, Schwarz J, Al-Rawi S, Hicks WL :
Advanced Soft Palate Cancer: The Clinical Importance of the Parapharyngeal Space. Otolaryngology Head & Neck Surgery (2005) 133(1):66-69.

Rigual N, Anderson G, Loree T, Wiseman SM, Alrawi S, Stoler D :
Molecular Prognosticators and Genomic Instability in Papillary Thyroid Cancer. Laryngoscope (2005) 115:1479-1485.

Stoler DL, Bartos JD, Swede H, Edge S, Winston J, Wiseman SM, Anderson G, Stoler D :
Genomic Instability In Invasive Breast Carcinoma Measured By Inter-Simple Sequence Repeat PCR. Breast Cancer Research & Treatment (2005) 1:1-4.

Rigual N, Lorre T, Wiseman SM, Douglas W, Lamonica D, Cheney R, Hicks W :
Sentinel Lymph Node Biopsy- A Rational Approach for Staging T2N0 Oral Cancer. Laryngoscope (2005) 115(12):2217-20.

Wiseman SM, Baliski C, Irvine R, Wilkins G, Filipenko D, Zhang H, Bugis S :
Hemithyroidectomy Is The Optimal Initial Surgical Approach To Individuals Undergoing Surgery For A Cytologic Diagnosis Of 'Follicular Neoplasm'. Annals of Surgical Oncology (2006) 13(3):1-8.

Messerer CL, Bugis SP, Baliski C, Wiseman SM :
Normocalcemic parathyroid carcinoma- an unusual clinical presentation. World Journal of Surgical Oncology (2006) 4(10):1-5.

Wiseman SM, Masoudi H, Niblock P, Turbin D, Rajput A, Hay J, Filipenko D, Huntsman D, Gilks :
Derangement Of The E-cadherin/catenin Complex Is Involved In Transformation Of Differentiated To Anaplastic Thyroid Carcinoma. American Journal of Surgery (2006) 191(5):581-587.

Melck A, Bugis S, Baliski C, Irvine R, Anderson D, Wilkins G, Zhang H, Wiseman SM :
Hemithyroidectomy- The Preferred Initial Surgical Approach For Management Of The 'Hurthle Cell Neoplasm'. American Journal of Surgery (2006) 191(5):593-597.

Swede H, Bartos JD, Chen N, Shaukat A, Dutt SS, McQuaid DA, Natarajan N, Rodriguez-Bigas MA, Nowak NJ, Wiseman SM, Alrawi S, Brenner BM, Petrelli NJ, Cummings KM, Stoler DL, Anderson GR :
Genomic profiles of colorectal cancers differ based on patient smoking status. Cancer Genetics & Cytogenetics (2006) 15;168(2):98-104.

Griffith O, Melck A, Jones S, Wiseman SM :
A Meta-analysis and Meta-review of Thyroid Cancer Gene Expression Profiling Studies Identifies Important Diagnostic Biomarkers. Journal of Clinical Oncology (2006) 24;31:5043-5051.

Wiseman SM, Masoudi H, Niblock P, Turbin D, Rajput A, Hay J, Bugis S, Filipenko D, Huntsman D, Gilks B :
Anaplastic Thyroid Carcinoma: Expression Profile Of Targets For Therapy Offers New Insights For Disease Treatment. In press Annals of Surgical Oncology (2007) 14;2:719-729.

Stoler D, Nowak N, Matsui S, Wiseman SM, Chen N, Dutt S, Bartos J, Loree TR, Rigual, NR, Hicks WL, Sait S, Anderson GR :
Comparative Genomic Instabilities of Thyroid and Colon Cancers. Archives of Otolaryngology/Head & Neck Surgery (2007) 133:457-463.

Wiseman S, Bugis S, MacFarlane J :
Jejunal Adenoma Presenting With Gastrointestinal Bleeding. Canadian Journal of Surgery (2007) 50:223-224.

Wiseman SM, Griffith O, Deen S, Rajput A, Masoudi H, Gilks B, Goldstein L, Gown A, Jones S: Identification of Molecular Markers Altered During Transformation Of Differentiated Into Anaplastic Thyroid Carcinoma. Archives of Surgery (2007) 142:717-727, discussion 727-9.

Kojic LD, Joshi B, Lajoie P, Le PU, Cox M, Turbin DA, Wiseman S, Nabi I:. Raft-dependent Endocytosis of Autocrine Motility Factor Is Phosphatidylinositol-3-Kinase-Dependent in Breast Carcinoma Cells. Journal of Biological Chemistry (2007) 282:29305-29313.

Melck A, Masoudi H, Griffith O, Rajput A, Wilkins G, Bugis S, Jones S, Wiseman S: Evaluation of a Panel of Cell Cycle Regulators in 205 Thyroid Lesions Reveals the Diagnostic and Prognostic Importance of p16, p21, Cyclin D1 and Cyclin E. Annals of Surgical Oncology (2007) 14:3403-3411.

Chooi WK, Brown J, Zetler P, Wiseman S, Cooperberg P: Imaging Of Acute Appendicitis And Its Impact On Negative Appendectomy And Perforation Rates: The St Paul's Experience. Canadian Association of Radiology Journal (2007) 58:220-224.

Chiu CG, St-Pierre P, Nabi IR, Wiseman SM: Autocrine Motility Factor Receptor: A Clinical Review. Expert Reviews of Anticancer Therapy. Expert Reviews of Anticancer Therapy (2008) 8:207-217.

Wiseman SM, MD, Griffith OL, Melck A, Masoudi H, Gown A, MD; Nabi IR, PhD; Jones SJ: Evaluation of Type 1 Growth Factor Receptor Family Expression in Benign and Malignant Thyroid Lesions. American Journal of Surgery (2008) 195:667-673.

Leung S, Griffith OL, Masoudi H, Gown a, Jones SJ, Phang PT, Wiseman SM: Clinical Utility Of Type 1 Growth Factor Receptor Expression In Colon Cancer. American Journal of Surgery (2008) 195:604-610.

Maizlin ZV, Wiseman SM, Vora P, Kirby JM, Mason AC, MD, Filipenko D, Brown JA: Hurthle Cell Neoplasms of Thyroid: Sonographic Appearance and Histologic Characteristics. Journal of Ultrasound Medicine (2008) 27:751-7.

Shoman N, Melck A, Irvine R, Bugis S, Zhang H, Holmes D, Wiseman, S: The Utility of Intraoperative Parathyroid Hormone Measurement In Predicting Post-parathyroidectomy Hypocalcemia. Journal of Otolaryngology (2008) 37:16-22.

Chiu CG, Harrisson P, Filipenko D, Wiseman SM: Thyroid Invasion by Locally Advanced Esophageal Cancer Masquerading as Anaplastic Carcinoma. Thyroid (2008) 18:799-800.

Kan M, Gill J, Wiseman SM: Colon and Rectal Cancer after Renal Transplantation: A Review. Expert Reviews of Anticancer Therapy (2008) 8:1339-1346.

Goetz J G, Lajoie P, Wiseman SM, Nabi IR: Caveolin-1 In Tumor Progression: The Good, The Bad And The Ugly. Cancer Metastasis Reviews (2008) 27:715-35.

Tee M, Vos P, Zetler P, Wiseman SM: Incidental Littoral Cell Angioma of the Spleen: Case Report. World Journal of Surgical Oncology (2008) 19;6:87-92.

Wiseman SM, Melck A, Masoudi H, Ghaaidi F, Gown A, Jones S, Griffith O: Molecular Phenotyping of Thyroid Tumors Identifies a Marker Panel for Differentiated Thyroid Cancer Diagnosis. Annals of Surgical Oncology (2008) 15:2811-2826.

Swanson T, Nanthakumar S, Bugis S, Wiseman S: Extrathyroidal Anaplastic Transformation Case Report & Review. Cancer Therapy (2008) 6:491-494.

Griffith OL, Chiu CG, Gown AM, Jones SJ, Wiseman SM: Biomarker Panel Diagnosis of Thyroid Cancer: A Critical Review. Expert Reviews of Anticancer Therapy (2008) 8:1399-413.

Joshi B, Strugnell S, Goetz J, Kojic LD, Cox ME, Wiseman SM, Nabi IR: Phospho-caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration. Cancer Research (2008) 68:8210-8220.

Kojic LD, Wiseman SM, Ghaidi F, Joshi B, Nedev H, Saragovi HU, Nabi IR: Raft-Dependent Endocytosis of Autocrine Motility Factor/Phosphoglucose Isomerase: A Drug Delivery Route for Tumor Cells. PLoS ONE (2008) 3:e3597. Epub Oct 31.

Lim JP, Irvine R, Bugis S, Holmes D, Wiseman SM: Intact Parathyroid Hormone Level Measured One Hour After Completion or Total Thyroidectomy Predicts Symptomatic Hypocalcemia. American Journal of Surgery (2008) 197:648-654.

Deen S, Grifith O, Masoudi H, Gown A, Jones S, Wiseman S: Anaplastic Thyroid Carcinoma Exhibits Intratumoral Molecular Homogeneity for a Therapeutic Target Panel. Anticancer Research (2009) 29:2437-44.

Vu L, Ambrose D, Vos P, Tiwari P, Rosengarten M, Wiseman S: Evaluation of MRI in the Diagnosis of Appendicitis During Pregnancy. Journal of Surgical Research (2009) 156:145-149.

Wiseman S, Levine D, Sexsmith G, Ling H: Aortopulmonary Window Parathyroid Adenoma. Journal of the American College of Surgeons (2009) 209:412.

Levine DS, Belzberg AS, Wiseman SM: Hybrid SPECT/CT imaging for Primary Hyperparathyroidism: case reports and pictorial review. Clinical Nuclear Medicine (2009) 34:779-784.

Johner A, Tiwari P, Zetler P, Wiseman SM: Abdominal Wall Desmoid Tumors Associated With Pregnancy: Current Concepts. Expert Rev Anticancer Therapy (2009) 9:1675-1682.

Levine DS, Wiseman SM: Fusion imaging for parathyroid localization in primary hyperparathyroidism. Expert Reviews of Anticancer Therapy (2010) 10:353-363.

Chiu CG, Griffith OL, Strugnell S, Nabi IR, Gown A, Walker B, Wiseman SM: The Emerging Role of Galectin-3 as a Diagnostic Marker in Thyroid Cancer. American Journal of Pathology (2010) 176(5):2067-81.

Swanson T, Chan S, Jones S, Bugis S, Irvine R, Belzberg A, Levine D, Wiseman SM: Determinants of Tc-99m Sestamibi SPECT Scan Sensitivity in Primary Hyperparathyroidism. American Journal of Surgery (2010) 199(5):614-20.

Chiu CG, Masoudi H, Leung S, Voduc DK, Gilks B, Hunstman DG, Wiseman SM: HER-3 Over-Expression is Prognostic of Reduced Breast Cancer Survival: A Study of 4,046 Patients. Annals of Surgery (2010) 251(6):1107-16.

Melck AL, Wiseman SM: Harmonic Scalpel versus Conventional Hemostasis in Thyroid Surgery: a Meta-analysis of Randomized Clinical Trials. International Journal of Surgical Oncology (2010).